Bradley E. Bernstein
Bradley Bernstein mapped the chromatin landscapes that let cancer cells switch identities and resist drugs.
Epigenomicist who defined bivalent chromatin domains and used single-cell approaches to show how glioma and other tumours exploit epigenetic plasticity.
| Title | Journal | Year |
|---|---|---|
| Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma | Science | 2014 |
Pages like this
not linked directly; found by shared links- IdeaBreak up the liquid droplets where oncogenic transcription happens
Shares Broad Institute of MIT and Harvard, Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET).
- IdeaAn open model of every cancer cell state, built from perturbation atlases
Shares Broad Institute of MIT and Harvard, Single-cell & spatial profiling.
- IdeaAn open foundation model of the cancer cell trained on perturbation data
Shares Broad Institute of MIT and Harvard, Single-cell & spatial profiling.
- IdeaImplant a tiny device that tests twenty drugs inside the patient's own tumour
Shares Single-cell & spatial profiling, Glioma & glioblastoma.
- IdeaReprogramme suppressive macrophages instead of trying to delete them
Shares Single-cell & spatial profiling, Glioma & glioblastoma.
- ProductVorasidenib
Shares Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET), Glioma & glioblastoma.
- InstitutionCancer Research UK Cambridge Centre / CRUK Cambridge Institute
Shares Single-cell & spatial profiling, Glioma & glioblastoma.
- InstitutionUniversity Hospital Zurich / Comprehensive Cancer Center Zurich
Shares Single-cell & spatial profiling, Glioma & glioblastoma.