Two-week pre-operative windows to compare combination biology head to head
Give patients a short course of one of several drug pairs in the gap before surgery and compare what happened inside the tumours. It is the fastest human test of whether a combination does anything.
Window-of-opportunity studies give a drug for 1 to 4 weeks between diagnosis and surgery and compare pre- and post-treatment tissue. Multi-arm windows randomising to several combinations with pharmacodynamic endpoints (proliferation, immune infiltration, target pathway suppression) can rank combinations by biological effect in under a year, before any efficacy trial.
- Too many combinations to test · There are thousands of possible drug pairs and sequences. Trials can test a few dozen a year.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
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not linked directly; found by shared links- IdeaLet the trial learn: response-adaptive allocation across many combination arms
Shares Pre-surgery platform trials that test combinations on pathological response in months, Too many combinations to test.
- IdeaImplant a tiny device that tests twenty drugs inside the patient's own tumour
Shares Single-cell & spatial profiling, Too many combinations to test, Preclinical models that do not predict people.
- IdeaAutomated combination discovery: patient-sample screens feeding Bayesian platform trials
Shares Too many combinations to test, Preclinical models that do not predict people, Colorectal cancer.
- IdeaA bone marrow niche on a chip to study human dormancy
Shares Single-cell & spatial profiling, Preclinical models that do not predict people.
- IdeaTest drugs on freshly cut slices of the patient's own tumour
Shares Single-cell & spatial profiling, Preclinical models that do not predict people.
- IdeaAn open foundation model of the cancer cell trained on perturbation data
Shares Single-cell & spatial profiling, Too many combinations to test, Preclinical models that do not predict people.
- IdeaZebrafish avatars for a drug answer within a week
Shares Preclinical models that do not predict people, Colorectal cancer.
- IdeaWhole-patient digital twins validated in prospective randomised trials
Shares Too many combinations to test, Preclinical models that do not predict people.