A urine DNA test to decide who with blood in the urine needs a camera test
Most people referred for blood in the urine do not have bladder cancer, yet all get cystoscopy. A urine DNA or methylation test could safely spare most of them.
Urinary methylation and mutation assays report high negative predictive value. Propose an RCT in the haematuria pathway: biomarker-negative patients randomised to deferred versus immediate cystoscopy, with missed muscle-invasive cancer as the safety endpoint and cystoscopies avoided as efficacy.
- Most lethal cancers are found late · Screening exists for only a few cancers. Pancreatic, ovarian, liver, oesophageal and most lung cancers are found when cure is unlikely.
- Overdiagnosis and false alarms · Finding more cancer is not the same as saving lives. Screening also finds cancers that would never have hurt anyone, and treats them.
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not linked directly; found by shared links- CompanyHarbinger Health
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