Registry-based randomised MCED trial: a million people, no study visits
Randomise people through the national health system, post the blood kit, and read cancer deaths off the registry. That is ten times cheaper per participant than a classic trial.
Swedish registry-based RCTs (TASTE, DETO2X) showed pragmatic randomisation at national scale at a fraction of usual cost. Propose an MCED trial that randomises through screening call/recall, draws blood at existing phlebotomy or mobile units, and uses cancer registry and death-certificate linkage for endpoints, with no in-person study visits.
- Most lethal cancers are found late · Screening exists for only a few cancers. Pancreatic, ovarian, liver, oesophageal and most lung cancers are found when cure is unlikely.
- Trials enrol too few, too slowly · Fewer than one in ten adults with cancer joins a trial. Trials close for lack of patients, not lack of ideas.
Pages like this
not linked directly; found by shared links- IdeaLet MCED trials read out on late-stage incidence, with mortality follow-up mandated
Shares NHS-Galleri: design of the largest randomised trial of a multi-cancer blood test, Stage shift, Multi-cancer early detection (MCED), Most lethal cancers are found late.
- IdeaNon-endoscopic screening for Barrett's oesophagus and early adenocarcinoma
Shares Stage shift, Multi-cancer early detection (MCED), Most lethal cancers are found late.
- TrialUKCTOCS
Shares Stage shift, Multi-cancer early detection (MCED), Most lethal cancers are found late.
- IdeaA cancer blood test for older people arriving at A&E with unexplained symptoms
Shares Multi-cancer early detection (MCED), Most lethal cancers are found late.
- IdeaRegistry-based randomised trials for oncology comparative effectiveness
Shares Karolinska University Hospital, Trials enrol too few, too slowly.
- TrialNHS-Galleri
Shares NHS-Galleri: design of the largest randomised trial of a multi-cancer blood test, Stage shift, Multi-cancer early detection (MCED), Most lethal cancers are found late.
- IdeaMolecular indolence classifiers bundled with every screening programme
Shares Stage shift, Multi-cancer early detection (MCED), Most lethal cancers are found late.
- IdeaOpen-source models that translate stage shift into lives saved, for every cancer