GLP-1 drugs to reverse endometrial precancer in women with obesity
Womb precancer in women with obesity is usually treated with a hormone coil or hysterectomy. Weight-loss drugs might reverse it and protect fertility.
Atypical endometrial hyperplasia progresses to cancer in roughly 30% of cases and obesity is the driver. Propose an RCT of GLP-1 receptor agonist plus levonorgestrel intrauterine system versus the intrauterine system alone, with histological regression at six months as the endpoint.
- Prevention we already have is not deployed · Around four in ten cancers are preventable with tools we already own: vaccines, tobacco control, weight, alcohol, sun and infection control.
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not linked directly; found by shared links- IdeaA trial of GLP-1 weight-loss drugs with cancer as the primary outcome
Shares GLP-1 receptor agonists and obesity-related cancer risk, Chemoprevention & risk-reducing surgery, Endometrial cancer, Prevention we already have is not deployed.
- IdeaRegulators accept shrinking of precancer as the endpoint for prevention drug approval
Shares Chemoprevention & risk-reducing surgery, Prevention we already have is not deployed.
- TechnologyBariatric surgery and cancer incidence
Shares GLP-1 receptor agonists and obesity-related cancer risk, Chemoprevention & risk-reducing surgery, Endometrial cancer, Prevention we already have is not deployed.
- IdeaLow-dose tamoxifen for high-risk women, prescribed by pharmacists and nurses
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- InstitutionMUSC Hollings Cancer Center
Shares Chemoprevention & risk-reducing surgery, Prevention we already have is not deployed.
- InstitutionUniversity of Arizona Cancer Center
Shares Chemoprevention & risk-reducing surgery, Prevention we already have is not deployed.
- IdeaGet every Lynch syndrome carrier onto the right dose of aspirin
Shares Chemoprevention & risk-reducing surgery, Prevention we already have is not deployed.
- Key paperCAPP2: two years of aspirin cuts bowel cancer in Lynch syndrome by more than a third over 10 years
Shares Chemoprevention & risk-reducing surgery, Endometrial cancer, Prevention we already have is not deployed.