A permanent platform trial for supportive-care interventions inside cooperative groups
Instead of one-off small studies, run a standing trial that continuously tests new treatments for side-effects, adding and dropping arms as evidence arrives.
Supportive-care trials are typically small, single-question and slow. Platform designs have accelerated oncology drug development (I-SPY, STAMPEDE). The proposal is a standing platform in the cooperative groups for symptom interventions (nausea, neuropathy, fatigue, mucositis, dermatologic toxicity), with common PRO endpoints, shared control arms and adaptive randomisation, embedded in routine care to keep costs low.
- Toxicity and quality of life are undervalued · Trials measure how long people live, not how they live. Side-effects are under-reported and under-treated.
- Trial design, endpoints and cost · A phase 3 trial takes years and hundreds of millions of dollars, and often answers a question that has already moved on.
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