A standing platform trial for every major cancer, funded as infrastructure
Rather than building a new trial from scratch for every drug, keep one permanent trial open per cancer where new treatments can be slotted in and dropped out, sharing the same patients, control group and infrastructure.
Perpetual multi-arm platform trials with a common control, Bayesian adaptive randomisation and pre-agreed arm entry and graduation rules, as in I-SPY 2 (breast), STAMPEDE (prostate) and GBM AGILE (glioblastoma). The proposal is to fund the fixed infrastructure (governance, sites, data, statistics) for each of the ten commonest cancers as a public or philanthropic good, with sponsors paying a per-arm fee.
- Trial design, endpoints and cost · A phase 3 trial takes years and hundreds of millions of dollars, and often answers a question that has already moved on.
- Trials enrol too few, too slowly · Fewer than one in ten adults with cancer joins a trial. Trials close for lack of patients, not lack of ideas.
- Too many combinations to test · There are thousands of possible drug pairs and sequences. Trials can test a few dozen a year.
Pages like this
not linked directly; found by shared links- IdeaCompeting sponsors share one control arm in the same indication
Shares Basket, umbrella, and platform trials, Trials enrol too few, too slowly, Trial design, endpoints and cost, Pancreatic ductal adenocarcinoma.
- IdeaShared concurrent control arms across sponsors' trials in the same setting
Shares Basket, umbrella, and platform trials, Too many combinations to test, Trials enrol too few, too slowly, Pancreatic ductal adenocarcinoma.
- IdeaA perpetual platform trial in every major cancer, funded as infrastructure
Shares Basket, umbrella, and platform trials, Too many combinations to test, Trial design, endpoints and cost, Glioma & glioblastoma.
- IdeaA standing platform trial that assigns treatment by how the tumour escaped
Shares Basket, umbrella, and platform trials, Trials enrol too few, too slowly, Trial design, endpoints and cost.
- IdeaA permanent neutral non-profit sponsor for multi-company platform trials
Shares Basket, umbrella, and platform trials, Too many combinations to test, Trial design, endpoints and cost, Glioma & glioblastoma.
- IdeaPre-consented cohorts that can be randomised to future trials (TwiCs)
Shares Trials enrol too few, too slowly, Trial design, endpoints and cost, Prostate cancer.
- IdeaA permanent platform trial for supportive-care interventions inside cooperative groups
Shares Basket, umbrella, and platform trials, Trial design, endpoints and cost.
- IdeaLet the trial learn: response-adaptive allocation across many combination arms
Shares Basket, umbrella, and platform trials, Too many combinations to test, Trial design, endpoints and cost.