Pet dogs with spontaneous cancer as a bridge before human trials
Dogs get cancers that closely resemble human ones, with real immune systems and years of natural history. Treating them, with owner consent, can test drugs in a way mice cannot.
Comparative oncology trials in client-owned dogs with spontaneous osteosarcoma, lymphoma, bladder cancer and glioma provide outbred, immunocompetent, spontaneously arising tumours with intact microenvironments. The NCI Comparative Oncology Trials Consortium has run such studies and informed human dosing for several agents. Capacity, standardisation and regulatory recognition, rather than concept, limit its use.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
- The valley of death between lab and product · Most academic discoveries die before anyone tests them in people because nobody funds the middle step.
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not linked directly; found by shared links- IdeaMulti-centre randomised animal trials before committing to a human trial
Shares The valley of death between lab and product, Preclinical models that do not predict people, National Cancer Institute (NIH).
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- InstitutionCancer Center at Illinois
Shares The valley of death between lab and product, Preclinical models that do not predict people.
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Shares Preclinical models that do not predict people, National Cancer Institute (NIH), Sarcomas (soft tissue, bone, GIST).
- InstitutionCancer Prevention and Research Institute of Texas
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- InstitutionThe V Foundation for Cancer Research
Shares The valley of death between lab and product, National Cancer Institute (NIH).
- IdeaA home for the animal and organoid experiments that failed
Shares Preclinical models that do not predict people, National Cancer Institute (NIH).
- IdeaPre-register animal efficacy studies like clinical trials
Shares Preclinical models that do not predict people, National Cancer Institute (NIH).