Pathologists order genomic profiling automatically at diagnosis of advanced cancer
Many patients with advanced lung or bowel cancer start treatment without the gene tests that would show whether a targeted drug would work. Let the pathologist order the full test the moment cancer is confirmed, without waiting for an oncologist.
Real-world data show that a substantial fraction of patients with advanced NSCLC begin first-line therapy before biomarker results are available or without full testing, forgoing targeted therapy. Reflex testing, ordered by the pathologist at diagnosis on defined tumour types and stages, shortens time to result and increases completeness. Tissue stewardship, funding, and a default panel need agreement. Some regions have adopted reflex testing; most have not.
- Fragmented care and guideline gaps · Patients fall between specialists, wait for referrals and often do not get the treatment guidelines say they should.
- Biomarkers are not validated or standardised · Tests that decide who gets a drug are often not validated prospectively and are measured differently in every lab.
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not linked directly; found by shared links- IdeaRegulators recognise each other's companion diagnostic approvals
Shares FoundationOne CDx / Liquid CDx, Companion diagnostics, Biomarkers are not validated or standardised.
- IdeaLabel every targetable mutation as truncal or branch on the report
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- IdeaPublish each laboratory's biomarker proficiency results
Shares Companion diagnostics, Fragmented care and guideline gaps, Biomarkers are not validated or standardised.
- CompanyLabcorp
Shares Companion diagnostics, Comprehensive genomic profiling.
- IdeaEvery pathology and genomic report ships with a signed plain-language version
Shares Next-generation sequencing (NGS), Comprehensive genomic profiling.
- IdeaA reliance pathway for companion diagnostics so the test arrives with the drug
Shares Companion diagnostics, Biomarkers are not validated or standardised.
- IdeaEvery tumour sequencing report lists open, nearby, matched trials pulled live
Shares Next-generation sequencing (NGS), Companion diagnostics, Comprehensive genomic profiling.
- TermGenomic profiling
Shares FoundationOne CDx / Liquid CDx, Next-generation sequencing (NGS), Comprehensive genomic profiling.