OnCo
drugsProductApproved2025

Telisotuzumab vedotin

Telisotuzumab vedotin (Emrelis) is the first c-MET-directed ADC, approved in 2025 for lung cancer with high c-MET protein.

Accelerated approval May 2025 for previously treated non-squamous NSCLC with high c-MET overexpression (LUMINOSITY: ORR ~35%). Confirmatory TeliMET NSCLC-01 ongoing.

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Payload: MMAE · 2D coordinates (no PubChem conformer)
PubChem
How it works, step by step · animated schematic, not to scale
Antibody-drug conjugate (ADC)
Mechanism, step by step
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1.Antibody binds c-MET on the tumour cell surface

Modality
ADC
Mechanism
Anti-c-MET antibody with MMAE.
Brand / code
Emrelis
Payload
MMAE
Linker
mc-vc-PABC
Dosing & schedule
Route
IV infusion
Schedule
1.9 mg/kg every 2 weeks
Monitoring
Peripheral neuropathy, ocular symptoms, ILD

Source: www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications. Doses are for orientation; the current label governs.

Medicare
Part B (clinician-administered)

Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. FDA accelerated approval 2025 for c-Met overexpressing NSCLC.

Commercial insurance
covered with prior authorisation

Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments. c-Met IHC result required.

Assistance programmes

20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.

Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.

Not appraisedSearch NICE
Notes
No UK marketing authorisation as of September 2026, so no NICE appraisal. Access only through a clinical trial or a company early access scheme.
NHS England
Not routinely funded

Sources: NICE search: telisotuzumab vedotin. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.

Regulatory

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  1. Jan 2022DesignationUS

    Breakthrough Therapy designation, c-MET overexpressing NSCLC source

  2. 14 May 2025ApprovalUS

    Accelerated approval, previously treated c-MET-high non-squamous NSCLC (LUMINOSITY) source

Approvals

RegionYearIndication
US2025c-MET-high non-squamous NSCLC, previously treated (accelerated)

Safety

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Toxicity profile
Adverse event
Peripheral neuropathy
Fatigue
Decreased appetite
Peripheral oedema
Nausea

Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.

Cost & access

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Cost & access
CountryReimbursement
United StatesMedicare Part B (physician-administered); commercial plans per formulary

List prices are manufacturer or Medicare figures where publicly disclosed; net prices after rebates are usually lower. Reimbursement changes; check the payer.

Trials

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ClinicalTrials.gov · phase 2/3
refreshed 2026-09-09
7 studies3 recruiting5 Phase 22 Phase 3
Search “Telisotuzumab vedotin” on ClinicalTrials.gov →
Counts are from a name search and may include unrelated studies; up to 100 studies are summarised.

Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
Telisotuzumab vedotin
intervention: Telisotuzumab vedotin
Open on ClinicalTrials.gov →

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Latest papers

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Literature trend17 papers in the last 12 months+21% vs prior 12How this is computed
Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"Telisotuzumab vedotin" OR ABSTRACT:"Telisotuzumab vedotin" OR TITLE:"Emrelis" OR ABSTRACT:"Emrelis") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Telisotuzumab vedotin, not a curated reading list.

Connected

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