Telisotuzumab vedotin
Telisotuzumab vedotin (Emrelis) is the first c-MET-directed ADC, approved in 2025 for lung cancer with high c-MET protein.
Accelerated approval May 2025 for previously treated non-squamous NSCLC with high c-MET overexpression (LUMINOSITY: ORR ~35%). Confirmatory TeliMET NSCLC-01 ongoing.
1.Antibody binds c-MET on the tumour cell surface
- Route
- IV infusion
- Schedule
- 1.9 mg/kg every 2 weeks
- Monitoring
- Peripheral neuropathy, ocular symptoms, ILD
Source: www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications. Doses are for orientation; the current label governs.
- Medicare
- Part B (clinician-administered)
Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. FDA accelerated approval 2025 for c-Met overexpressing NSCLC.
- Commercial insurance
- covered with prior authorisation
Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments. c-Met IHC result required.
- Assistance programmes
- myAbbVie Assist
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.
- Notes
- No UK marketing authorisation as of September 2026, so no NICE appraisal. Access only through a clinical trial or a company early access scheme.
- NHS England
- Not routinely funded
Sources: NICE search: telisotuzumab vedotin. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
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- Jan 2022DesignationUS
Breakthrough Therapy designation, c-MET overexpressing NSCLC source
- 14 May 2025ApprovalUS
Accelerated approval, previously treated c-MET-high non-squamous NSCLC (LUMINOSITY) source
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2025 | c-MET-high non-squamous NSCLC, previously treated (accelerated) |
| Adverse event |
|---|
| Peripheral neuropathy |
| Fatigue |
| Decreased appetite |
| Peripheral oedema |
| Nausea |
Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
| Country | Reimbursement | List price | Assistance |
|---|---|---|---|
| United States | Medicare Part B (physician-administered); commercial plans per formulary | not disclosed | — |
List prices are manufacturer or Medicare figures where publicly disclosed; net prices after rebates are usually lower. Reimbursement changes; check the payer.
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Telisotuzumab vedotin" OR ABSTRACT:"Telisotuzumab vedotin" OR TITLE:"Emrelis" OR ABSTRACT:"Emrelis") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Telisotuzumab vedotin, not a curated reading list.
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