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Capmatinib & tepotinib

Capmatinib and tepotinib are two pills for the roughly 3% of lung cancers with a MET exon 14 skipping mutation.

Capmatinib (GEOMETRY mono-1: ORR 68% treatment-naive) approved 2020, full approval 2022; tepotinib (VISION: ORR ~57%) approved 2021, full approval 2024. Peripheral oedema is the class toxicity. MET amplification as an EGFR-TKI escape route is instead addressed by amivantamab and MET ADCs.

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Capmatinib
PubChem
Modality
Small-molecule kinase inhibitors (MET)
Mechanism
Highly selective type Ib MET inhibitors.
Brand / code
Tabrecta / Tepmetko
Medicare
Part D (self-administered)

Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026). Both Tabrecta and Tepmetko are Part D specialty drugs.

Commercial insurance
covered with prior authorisation

Covered for FDA-labelled and NCCN-listed uses, but almost always behind prior authorisation confirming diagnosis, biomarker and line of therapy; dispensed through a specialty pharmacy. MET exon 14 skipping by an approved test.

Part D out-of-pocket capped at $2,000 (2025) / $2,100 (2026). Medicare patients cannot use manufacturer co-pay cards; charity funds (PAN, HealthWell, CancerCare) and the Extra Help subsidy are the routes.

Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.

NICE recommendedNICE TA789 · 2022SMC: accepted
Appraised for
Tepotinib for MET exon 14 skipping advanced NSCLC
Notes
Capmatinib has no UK licence; tepotinib is the NHS option.
NHS England
Routinely funded for the appraised indication (or via managed access)

Sources: NICE TA789 · SMC advice: tepotinib. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.

Regulatory

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Approvals

RegionYearIndication
US2020MET exon 14 skipping NSCLC (capmatinib; tepotinib 2021)

Trials

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Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
Capmatinib & tepotinib
intervention: Capmatinib & tepotinib
Open on ClinicalTrials.gov →

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Latest papers

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Literature trend4 papers in the last 12 months-20% vs prior 12How this is computed
Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"Capmatinib & tepotinib" OR ABSTRACT:"Capmatinib & tepotinib" OR TITLE:"Tabrecta" OR ABSTRACT:"Tabrecta" OR TITLE:"Tepmetko" OR ABSTRACT:"Tepmetko") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Capmatinib & tepotinib, not a curated reading list.

Connected

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