177Lu-edotreotide
A second lutetium radioligand for neuroendocrine tumours that beat the standard pill everolimus in a head-to-head trial and is awaiting an FDA decision.
COMPETE (Lancet 2025; 309 patients, grade 1-2 GEP-NETs): PFS 23.9 vs 14.1 months versus everolimus (HR 0.67); ORR significantly higher; interim OS 63.4 vs 58.7 months not significant (HR 0.78). Uses non-carrier-added 177Lu from ITM's own supply. NDA accepted with PDUFA 28 August 2026. COMPOSE (grade 2-3, versus CAPTEM/everolimus/FOLFOX) ongoing.
- Route
- Intravenous
- Schedule
- 7.5 GBq every 3 months × 4 with amino-acid renal protection
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Trials
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"177Lu-edotreotide" OR ABSTRACT:"177Lu-edotreotide" OR TITLE:"ITM-11" OR ABSTRACT:"ITM-11" OR TITLE:"n.c.a. 177Lu-DOTATOC" OR ABSTRACT:"n.c.a. 177Lu-DOTATOC") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about 177Lu-edotreotide, not a curated reading list.
Pages like this
not linked directly; found by shared links- IdeaSSTR antagonist radioligands to increase tumour dose
Shares Peptide receptor radionuclide therapy (PRRT), Somatostatin receptor 2, Neuroendocrine tumours.
- TechnologySomatostatin receptor PET (68Ga/64Cu-DOTATATE)
Shares SSTR PET → PRRT, Peptide receptor radionuclide therapy (PRRT), Somatostatin receptor 2, Neuroendocrine tumours.
- TermPRRT (peptide receptor radionuclide therapy)
Shares Peptide receptor radionuclide therapy (PRRT), Somatostatin receptor 2, Neuroendocrine tumours, Radioligand therapy (beta emitters).
- ProductGallium-68 DOTATATE (and Cu-64 DOTATATE)
Shares Peptide receptor radionuclide therapy (PRRT), Somatostatin receptor 2, Neuroendocrine tumours, Radioligand therapy (beta emitters).
- PersonEmily K. Bergsland
Shares Somatostatin receptor 2, Neuroendocrine tumours, Radioligand therapy (beta emitters).
- CompanyRadioMedix
Shares Peptide receptor radionuclide therapy (PRRT), Somatostatin receptor 2, Neuroendocrine tumours.
- InstitutionHolden Comprehensive Cancer Center, University of Iowa
Shares Somatostatin receptor 2, Neuroendocrine tumours, Radioligand therapy (beta emitters).
- ProductLutetium-177 dotatate
Shares SSTR PET → PRRT, Dosimetry-personalised PRRT instead of four fixed cycles, Peptide receptor radionuclide therapy (PRRT), Somatostatin receptor 2.