Gallium-68 DOTATATE (and Cu-64 DOTATATE)
The PET scan for neuroendocrine tumours that finds far more disease than older scans and confirms eligibility for lutetium radioligand therapy (the theranostic pair).
Ga-68 DOTATATE (Netspot, kit) approved June 2016; Cu-64 DOTATATE (Detectnet, 12.7-hour half-life allows central production) approved September 2020; Ga-68 DOTATOC (2019, academic). Changes management in about a third of patients; required before Lu-177 DOTATATE (Lutathera). Also images meningioma and paraganglioma.
- Medicare
- Part B (clinician-administered)
Diagnostic radiopharmaceutical billed with the PET/CT scan under Part B for neuroendocrine tumours (Netspot, Detectnet).
- Commercial insurance
- covered with prior authorisation
Covered for neuroendocrine tumour staging and Lutathera eligibility with prior authorisation of the PET scan.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B) · Medicare.gov: Diagnostic non-laboratory tests (imaging). Not medical or financial advice; verify with your plan.
- Appraised for
- Somatostatin receptor PET for neuroendocrine tumours
- Notes
- Available at NHS PET centres and required before Lutathera (TA539). No TA.
- NHS England
- Routinely funded for the appraised indication (or via managed access)
Sources: NICE search: gallium-68 DOTATATE PET. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2016 | PET localisation of SSTR-positive neuroendocrine tumours (Ga-68 DOTATATE) |
| US | 2020 | Same (Cu-64 DOTATATE) |
| EU | 2017 | SomaKit TOC (Ga-68 DOTATOC) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Gallium-68 DOTATATE" OR ABSTRACT:"Gallium-68 DOTATATE" OR TITLE:"and Cu-64 DOTATATE" OR ABSTRACT:"and Cu-64 DOTATATE" OR TITLE:"Netspot" OR ABSTRACT:"Netspot" OR TITLE:"Detectnet" OR ABSTRACT:"Detectnet") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Gallium-68 DOTATATE (and Cu-64 DOTATATE), not a curated reading list.
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