Cabazitaxel
A second taxane that works after docetaxel and beat a second hormone pill head-to-head (CARD).
TROPIC (2010) post-docetaxel OS benefit; CARD (2019) superior to abiraterone/enzalutamide switch after prior ARPI and docetaxel; comparator in TheraP (lost to 177Lu-PSMA-617 on PSA50) and XALute.
- Medicare
- Part B (clinician-administered)
Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. Generics entered the US market in 2021–2024 after patent litigation.
- Commercial insurance
- covered with prior authorisation
Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments. Plans typically require prior docetaxel.
- Assistance programmes
- Sanofi CareASSIST
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.
- Appraised for
- Metastatic hormone-relapsed prostate cancer after docetaxel
- NHS England
- Routinely funded for the appraised indication (or via managed access)
Sources: NICE TA391 · SMC advice: cabazitaxel. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2010 | mCRPC after docetaxel |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"Cabazitaxel" OR ABSTRACT:"Cabazitaxel" OR TITLE:"Jevtana" OR ABSTRACT:"Jevtana") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cabazitaxel, not a curated reading list.
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