OnCo
drugsProductNot mapped hereapproved

Eribulin

A sea-sponge-derived chemotherapy that extended survival in heavily pretreated breast cancer and in liposarcoma, where almost nothing else had.

EMBRACE (Lancet 2011): OS 13.1 vs 10.6 months versus treatment of physician's choice in pretreated metastatic breast cancer. Liposarcoma approval 2016 (OS 15.6 vs 8.4 months versus dacarbazine in the liposarcoma subgroup). Neuropathy and neutropenia; the payload of the ADC MORAb-202 (farletuzumab ecteribulin).

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Eribulin · 2D coordinates (no PubChem conformer)
PubChem
Modality
Synthetic halichondrin B analogue (microtubule dynamics inhibitor)
Mechanism
Binds the plus ends of microtubules, suppressing growth without affecting shortening; also reverses EMT and remodels tumour vasculature.
Brand / code
Halaven
Medicare
Part B (clinician-administered)

Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. Generic eribulin has been approved.

Commercial insurance
covered with prior authorisation

Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments. Plans typically require two prior chemotherapy regimens for metastatic breast cancer, per the label.

Assistance programmes

20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.

Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.

NICE recommendedNICE TA423 · 2016SMC: accepted
Appraised for
Locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
NHS England
Routinely funded for the appraised indication (or via managed access)

Sources: NICE TA423 · SMC advice: eribulin. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.

Regulatory

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Approvals

RegionYearIndication
US2010Metastatic breast cancer after ≥2 regimens including an anthracycline and a taxane
US2016Unresectable or metastatic liposarcoma after anthracycline
EU2011Metastatic breast cancer; liposarcoma (2016)

Trials

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ClinicalTrials.gov · phase 2/3
refreshed 2026-09-09
199 studies21 recruiting68 Phase 232 Phase 3
Search “Eribulin” on ClinicalTrials.gov →
Counts are from a name search and may include unrelated studies; up to 100 studies are summarised.

Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
Eribulin
intervention: Eribulin
Open on ClinicalTrials.gov →

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Latest papers

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Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"Eribulin" OR ABSTRACT:"Eribulin" OR TITLE:"Halaven" OR ABSTRACT:"Halaven") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Eribulin, not a curated reading list.

Connected

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