INT-0091 (Ewing sarcoma)
Adding ifosfamide and etoposide improved cure rates for localised Ewing sarcoma, setting the backbone still used today.
Non-metastatic patients: 5-year EFS 69% vs 54% (NEJM 2003); no benefit in metastatic disease. Foundation of VDC/IE; interval compression (AEWS0031) later improved it further.
- 69 vs 54 out of 100 free of a major event at 5 years with VDC/IE compared with VDC; 15 more per 100.
- Roughly one extra person helped for every 7 treated. That is a rough figure taken from the two percentages, not a guarantee for any one person.
- The p-value (0.005) says a difference this large would rarely happen by chance; it does not say how large or how useful the difference is.
- This is a surrogate endpoint: it measures the cancer being controlled or absent on scans and tests, which often, but not always, translates into living longer.
- These results apply to the people the trial enrolled: Newly diagnosed Ewing sarcoma: VDC alone vs VDC alternating with ifosfamide-etoposide. People in a different situation may not see the same effect.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
Pages like this
not linked directly; found by shared links- TrialANNOUNCE
- TrialEuro Ewing 2012
Shares Ifosfamide, Doxorubicin, Sarcomas (soft tissue, bone, GIST).
- PairingCaution: cumulative anthracycline dose and the heart
- PersonDouglas S. Hawkins
Shares Children's Oncology Group (COG), Sarcomas (soft tissue, bone, GIST).
- IdeaAn international consortium pooling the outcome of every treated child with cancer
Shares Children's Oncology Group (COG), Sarcomas (soft tissue, bone, GIST).
- TrialISG-STS 1001
- IdeaEscrow a share of adult revenue until the paediatric study is done
Shares Children's Oncology Group (COG), Sarcomas (soft tissue, bone, GIST).
- IdeaInhaled immune therapy to make the lung hostile to arriving tumour cells
Shares Children's Oncology Group (COG), Sarcomas (soft tissue, bone, GIST).