Salvage therapy
Treatment given after the first treatment has failed or the cancer has come back, aiming to rescue the situation. It can still be curative (salvage surgery after organ-preservation fails) or a later line of palliation.
Salvage surgery removes the organ when chemoradiation or watch-and-wait fails (laryngectomy, cystectomy, abdominoperineal resection, TME after regrowth). Salvage radiotherapy treats a rising PSA after prostatectomy; salvage chemotherapy (ICE, DHAP, GDP) followed by autologous transplant was the standard for relapsed lymphoma until CAR-T proved superior in second line (ZUMA-7, TRANSFORM). Organ-preservation strategies are only safe where salvage is feasible and centres have the surgical capacity to deliver it.
Pages like this
not linked directly; found by shared links- TermApheresis (leukapheresis)
Shares Bridging therapy, Autologous stem cell transplant (ASCT).
- PairingEarly relapse: CAR-T before transplant
- Key paperTRANSFORM: liso-cel CAR-T versus salvage chemotherapy and transplant in early-relapsing large B-cell lymphoma
- Key paperZUMA-7: axi-cel CAR-T instead of salvage chemotherapy and transplant for large B-cell lymphoma that relapses early