Prophylactic cranial irradiation (PCI)
Giving the brain a preventive dose of radiation when a cancer is very likely to spread there, before any metastasis can be seen; mainly small-cell lung cancer.
Small-cell lung cancer spreads to the brain in over half of patients, and PCI (25 Gy in 10 fractions) halved brain relapse and improved survival in limited-stage disease in the 1990s meta-analysis. Its value in extensive-stage disease and in the era of routine MRI staging is disputed (the Japanese Takahashi trial found no benefit with MRI surveillance), so the SWOG S1827 MAVERICK trial is comparing PCI with MRI surveillance while cognitive side effects push practice toward surveillance. In childhood leukaemia it has been replaced by intrathecal chemotherapy.
Pages like this
not linked directly; found by shared links- TermLeptomeningeal disease
Shares Whole-brain radiotherapy (WBRT), Intrathecal therapy (lumbar puncture, Ommaya reservoir), Brain metastases (intracranial disease).
- TermStereotactic radiosurgery (SRS)
Shares Whole-brain radiotherapy (WBRT), Brain metastases (intracranial disease).
- TermCNS penetration (brain-penetrant drugs)
Shares Intrathecal therapy (lumbar puncture, Ommaya reservoir), Brain metastases (intracranial disease).
- IdeaMRI surveillance replaces prophylactic cranial irradiation in SCLC
Shares Prophylactic cranial irradiation vs MRI surveillance, Small-cell lung cancer.
- TrialADRIATIC
Shares Prophylactic cranial irradiation vs MRI surveillance, Small-cell lung cancer.
- TermLimited-stage vs extensive-stage (SCLC)
Shares Prophylactic cranial irradiation vs MRI surveillance, Small-cell lung cancer.
- TermLimited-stage vs extensive-stage (small-cell lung cancer)
Shares Prophylactic cranial irradiation vs MRI surveillance, Small-cell lung cancer.
- PathwayThe blood–brain barrier & brain metastasis
Shares Prophylactic cranial irradiation vs MRI surveillance, Small-cell lung cancer.