Risk-reducing and opportunistic salpingectomy
Removing the fallopian tubes, where most ovarian cancer starts, during other pelvic surgery or in women at inherited risk.
Because high-grade serous cancer originates in the tubal fimbria, removing the tubes at hysterectomy or instead of tubal ligation (opportunistic salpingectomy) is recommended by ACOG and SGO for average-risk women. In BRCA carriers, salpingo-oophorectomy by age 35-45 remains standard; salpingectomy with delayed oophorectomy (TUBA-WISP II, SOROCk) is under study to postpone surgical menopause. Population data from British Columbia show falling incidence after policy adoption.
How it works
Removing the fallopian tubes eliminates the tissue of origin of high-grade serous carcinoma while sparing ovarian hormone production.
- Prevents the deadliest ovarian cancer type without hormonal consequences
- Adds little time or risk to existing surgery
- Does not prevent non-tubal ovarian cancers
- Benefit for BRCA carriers versus oophorectomy still unproven
Latest papers
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