MIBG imaging and 131I-MIBG therapy
A noradrenaline look-alike that neuroblastoma cells swallow: labelled with a small amount of radioactivity it shows the tumour on a scan; with a large amount it treats it.
123I-MIBG scintigraphy/SPECT is the standard staging scan (Curie score) in neuroblastoma, being partly replaced by 18F-MFBG PET. Therapeutic 131I-MIBG produces responses in ~30% of relapsed patients; COG ANBL1531 tested adding it to induction (results awaited). Also used in pheochromocytoma/paraganglioma (Azedra, discontinued 2024).
How it works
Norepinephrine transporter (NET) uptake concentrates radio-iodinated MIBG in adrenergic tumours; 131I delivers beta radiation.
- Theranostic pair with decades of use
- Targets NET-positive disease irrespective of GD2
- Prolonged isolation and radiation precautions in children
- Myelosuppression requiring stem-cell support at high doses
- Azedra withdrawal reduced supply
Latest papers
topQuery for this technology: (TITLE:"MIBG imaging and 131I-MIBG therapy" OR ABSTRACT:"MIBG imaging and 131I-MIBG therapy") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MIBG imaging and 131I-MIBG therapy, not a curated reading list.
Pages like this
not linked directly; found by shared links- PersonKatherine K. Matthay
Shares 131I-MIBG (iobenguane I-131) therapy, Neuroblastoma (paediatric), Radioligand therapy (beta emitters).
- CompanyMIM Software (GE HealthCare)
Shares SPECT & bone scan, Radioligand therapy (beta emitters).
- TargetGRPR (gastrin-releasing peptide receptor)
Shares PET (positron emission tomography), Radioligand therapy (beta emitters).
- IdeaDosimetry-personalised PRRT instead of four fixed cycles
Shares SPECT & bone scan, Neuroendocrine tumours.
- IdeaOne global paediatric cancer development plan instead of separate FDA and EMA plans
Shares Neuroblastoma (paediatric), Rare and paediatric cancers without markets.
- IdeaMandatory national virtual tumour boards for rare and complex cancers
Shares Neuroendocrine tumours, Rare and paediatric cancers without markets.
- TrialNaxitamab Study 201
Shares Neuroblastoma (paediatric), Rare and paediatric cancers without markets.
- PersonThomas A. Hope
Shares PET (positron emission tomography), Radioligand therapy (beta emitters).