OnCo
institutionsInstitution

UCSF Helen Diller Family Comprehensive Cancer Center

UCSF is the birthplace of oncogene biology (Bishop, Varmus) and KRAS G12C drugging (Shokat), and a leader in I-SPY adaptive breast trials.

Nobel-winning oncogene discovery; Shokat's switch-II pocket; I-SPY 2 platform trial (Esserman); UCSF500 panel; neuro-oncology and prostate (PSMA PET pioneer, Hope).

Location
San Francisco, US
Type
cancer center · University of California, San Francisco
Newsweek 2026 oncology rank
#33
NCI designation
comprehensive
OnCo score
#21 · 70 points (27 Newsweek + 15 NCI + 28 from 14 linked objects) · ranking

Programmes

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  • I-SPY 2 platform trial
  • KRAS chemistry
  • PSMA PET
  • Neuro-oncology

People

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Alan Ashworth
President, UCSF Helen Diller Family Comprehensive Cancer Center
DNA repairSynthetic lethalityBRCA

Co-discovered that BRCA-deficient cancers die when PARP is blocked, the idea behind an entire drug class.

Alan P. Venook
Shorenstein Associate Director for Program Development, UCSF Helen Diller Family Comprehensive Cancer Center
Colorectal cancerLiver cancerCooperative group trials

GI oncologist who led CALGB/SWOG 80405 and helped show that tumour side matters in colorectal cancer.

Emily K. Bergsland
Professor of Medicine; Associate Director for Education, UCSF Helen Diller Family Comprehensive Cancer Center
Neuroendocrine tumoursGastrointestinal oncologyClinical trials

Neuroendocrine tumour specialist who helps design the trials that set treatment for these rare cancers.

Eric J. Small
Deputy Director and Chief Scientific Officer, UCSF Helen Diller Family Comprehensive Cancer Center; ASCO President 2025-2026
Prostate cancerGenitourinary oncologyClinical trials

Prostate cancer trialist who helped bring abiraterone and sipuleucel-T to patients, and led ASCO in 2025-26.

Frank McCormick
Professor, UCSF Helen Diller Family Comprehensive Cancer Center; former Scientific Lead, NCI RAS Initiative
RAS biologySignal transductionDrug discovery

RAS biologist who founded Onyx Pharmaceuticals and led the NCI's national effort to drug RAS.

Katherine K. Matthay
Professor Emerita of Pediatrics, UCSF; Children's Oncology Group neuroblastoma investigator
Paediatric oncologyNeuroblastomaMIBG therapy

Paediatric oncologist whose trials established transplant and 13-cis-retinoic acid for high-risk neuroblastoma.

Kevan M. Shokat
Professor of Cellular and Molecular Pharmacology, UCSF; Investigator, Howard Hughes Medical Institute
Chemical biologyKRASKinase inhibitors

The chemist whose lab found the hidden pocket in KRAS G12C that made the 'undruggable' target druggable.

Laura J. Esserman
Director, UCSF Carol Franc Buck Breast Care Center; Principal Investigator, I-SPY trials
Breast cancerAdaptive trial designScreening

Breast surgeon who built the I-SPY platform, the adaptive trial that tests new drugs before surgery.

Rahul Aggarwal
Associate Director for Clinical Sciences, UCSF Helen Diller Family Comprehensive Cancer Center
Prostate cancerNeuroendocrine prostate cancerPSMA theranostics

Prostate oncologist studying how tumours transform to escape hormone therapy and how to target them with radioligands.

Thomas A. Hope
Professor of Radiology; Chief of Nuclear Medicine, UCSF
Nuclear medicinePSMA PETTheranostics

Nuclear medicine physician who led the trials that got PSMA PET approved in the United States.

Key papers

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Connected

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