OnCo
ideasIdea

Give negative trials plenary slots at the big cancer conferences

Conferences headline the trials that worked. A dedicated plenary for important trials that failed would make the lessons impossible to miss.

Practice-changing negative trials (for example those that stop an established practice) are sometimes presented, but most negative trials are relegated to posters or never submitted. A standing plenary session at ASCO, ESMO and AACR for high-importance negative and reversal trials, with a discussant focused on lessons for design and biology, would raise the status of reporting failure.

Hypothesis
Introduction of a negative-results plenary increases submission of negative phase 3 trials to the meeting by at least 50% and their subsequent full publication rate.
Rationale
Conference prestige drives what is submitted and written up. The ASCO 'Trials in Progress' session shows that a new session type can change behaviour.
What would test it
Run the session at one meeting for two years; count negative-trial submissions and publications before and after.
Maturity
speculative
Who has to act
research
Cost to try
Small (under $1M)
Years to first evidence
1
Bottlenecks it attacks
  • Failures are hidden · Negative trials, failed drugs and abandoned programmes are rarely published, so the same mistakes are repeated.
  • Knowledge reaches practice too slowly · Knowledge diffusion is slow: it takes years for a proven result to change what most patients receive, and no one can keep up with the literature.

Connected

5top

Pages like this

not linked directly; found by shared links