Let adolescents from age 12 into adult trials when the cancer biology is the same
Teenagers with cancers that are really adult cancers, like melanoma or sarcoma, are barred from adult trials by an age line at 18. Letting them in from age 12, where biology and dosing allow, would give them access years earlier.
Adult oncology trials in histologies that occur in adolescents (melanoma, sarcomas, Hodgkin lymphoma, germ cell tumours, colorectal in Lynch syndrome) set the minimum age at 12 with weight-based dosing where required and paediatric assent, as FDA guidance permits. Sponsors would need to justify an age floor above 12 in these histologies.
- Trials do not represent the people who get cancer · Older, Black, Hispanic, Asian, rural, poor and multimorbid patients are under-represented, so results may not apply to them.
- Rare and paediatric cancers without markets · Taken together rare cancers are a fifth of all cancers, but each one alone is too small for a company to invest in.
Pages like this
not linked directly; found by shared links- CompanySpringWorks Therapeutics (Merck KGaA)
Shares Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- IdeaMandatory national virtual tumour boards for rare and complex cancers
Shares Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- IdeaOne legal framework for pooling rare cancer data across borders
Shares Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- IdeaStop over-excluding people who could become pregnant; study pregnancy exposure
Shares Trials do not represent the people who get cancer, Hodgkin lymphoma.
- IdeaGuaranteed-quality childhood cancer medicines free of charge in 50 countries
Shares Hodgkin lymphoma, Rare and paediatric cancers without markets.
- IdeaA funded expert second opinion for every new high-stakes or rare cancer diagnosis
Shares Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- TermFNCLCC grade (soft-tissue sarcoma)
Shares Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- PersonTerry Fox
Shares Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).