AI malignancy scores to end repeat scans and biopsies for benign lung nodules
Most lung nodules on CT are harmless but trigger years of follow-up scans. A validated AI score could discharge low-risk nodules immediately.
Nodule AI improves discrimination over the Brock model. Propose an RCT where AI-low-risk nodules (under 1% malignancy) are discharged at baseline versus standard follow-up, with missed cancer at three years as safety and scans and biopsies avoided as efficacy.
- Overdiagnosis and false alarms · Finding more cancer is not the same as saving lives. Screening also finds cancers that would never have hurt anyone, and treats them.
- AI that is built but not validated or deployed · Thousands of cancer AI models are published; a handful are in clinical use, and fewer have shown they help patients.
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