Replace six-monthly ultrasound with a blood test for liver cancer in cirrhosis
People with cirrhosis are meant to have ultrasound scans twice a year, but most do not. A blood test done with their routine liver bloods could catch liver cancer earlier.
GALAD and methylation or protein panels show sensitivity above ultrasound for early hepatocellular carcinoma, while adherence to ultrasound surveillance is under 30% in many settings. Propose a randomised trial of blood-based surveillance (MRI for positives) versus ultrasound, with early-stage detection and adherence as endpoints.
- Most lethal cancers are found late · Screening exists for only a few cancers. Pancreatic, ovarian, liver, oesophageal and most lung cancers are found when cure is unlikely.
Pages like this
not linked directly; found by shared links- IdeaNew diabetes after 50 plus weight loss triggers a pancreatic cancer check
Shares MRI, Most lethal cancers are found late, Liquid biopsy (ctDNA).
- IdeaMobile diagnostic units that biopsy, scan and treat on the same visit
- IdeaTailored screening for second cancers in survivors with known high-risk exposures
Shares MRI, Most lethal cancers are found late.
- TechnologyHCC surveillance in cirrhosis (ultrasound + AFP)
Shares Ultrasound, MRI, Most lethal cancers are found late, Hepatocellular carcinoma.
- IdeaProstate active surveillance without scheduled biopsies: MRI and blood tests decide
Shares MRI, Liquid biopsy (ctDNA).
- IdeaOne-stop breast clinics: imaging, biopsy and a preliminary answer in a single visit
- IdeaMRI-first prostate screening with genetic pre-selection
Shares MRI, Most lethal cancers are found late.
- IdeaBlood EBV DNA screening for nasopharyngeal cancer across southern China and Southeast Asia
Shares Most lethal cancers are found late, Liquid biopsy (ctDNA).