Measure and treat chemo brain with objective digital cognitive testing
Many people report thinking and memory problems after cancer treatment. Measure it properly with short phone-based tests and run trials of treatments.
Cancer-related cognitive impairment is common, under-recognised and lacks validated treatments; assessment relies on lengthy neuropsychological batteries. Smartphone-based cognitive tests can capture trajectories cheaply. The proposal is a programme pairing digital cognitive monitoring in trials and clinics with a platform trial of interventions (exercise, cognitive rehabilitation, methylphenidate, memantine, sleep interventions) and biological correlates (inflammatory markers, imaging).
- Toxicity and quality of life are undervalued · Trials measure how long people live, not how they live. Side-effects are under-reported and under-treated.
- Survivorship and late effects are neglected · Tens of millions of people live after cancer with heart damage, infertility, second cancers and fear, and few services.
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