Track clones in blood with methylation patterns instead of mutations
Tumour DNA in blood can be told apart by chemical marks as well as mutations. Marks are more numerous and cheaper to read, so they could track more sub-populations for less money.
Mutation-based clone tracking needs deep whole-exome or genome sequencing of tumour and plasma. Methylation haplotypes are clone-stable, abundant, and readable with targeted enrichment at lower cost. The proposal is to define clone-specific methylation haplotypes from multi-region tumour tissue and monitor their plasma fractions as a low-cost clonal evolution assay.
- Tumour heterogeneity and clonal evolution · A tumour is many tumours. Treatments that kill most cells leave the rest to grow back, changed.
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not linked directly; found by shared links- InstitutionPrince of Wales Hospital / Chinese University of Hong Kong
Shares GRAIL, DNA methylation profiling, Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
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Shares Tumour heterogeneity and clonal evolution, Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
- PersonSarah-Jane Dawson
Shares Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).