OnCo
drugsProductEstablished

MammaPrint (70-gene signature)

A 70-gene test that tells whether an early breast cancer is genomically low or high risk, used to decide who can skip chemotherapy.

MammaPrint is Agendia's 70-gene signature. MINDACT (n=6,693): women with high clinical but low genomic risk had 5-year distant metastasis-free survival of 94.7% without chemotherapy; 8-year update showed a small benefit of chemotherapy in women under 50. FDA-cleared (2007), NCCN-listed alongside Oncotype DX; BluePrint adds molecular subtyping. Also used to identify 'ultralow' risk tumours with indolent behaviour.

Schematic of the modality · Gene-expression prognostic assay · not a molecule; see the RNA sequencing & expression profiling page
Modality
Gene-expression prognostic assay
Mechanism
Microarray or NGS expression of 70 genes → dichotomous low/high risk.

Regulatory

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Approvals

RegionYearIndication
US2007FDA 510(k) clearance for recurrence risk in early breast cancer

Trials

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ClinicalTrials.gov · phase 2/3
refreshed 2026-09-09
3 studies1 recruiting2 Phase 21 Phase 3
Search “MammaPrint” on ClinicalTrials.gov →
Counts are from a name search and may include unrelated studies; up to 100 studies are summarised.

Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
MammaPrint (70-gene signature)
intervention: MammaPrint
Open on ClinicalTrials.gov →

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Landmark trials in OnCo

TAILORx

Latest papers

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Literature trend41 papers in the last 12 months+5% vs prior 12How this is computed
Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"MammaPrint" OR ABSTRACT:"MammaPrint" OR TITLE:"70-gene signature" OR ABSTRACT:"70-gene signature") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MammaPrint (70-gene signature), not a curated reading list.

Connected

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Pages like this

not linked directly; found by shared links

cancers

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HR-positive / HER2-negative breast cancer

technologies

2
Companion diagnosticsRNA sequencing & expression profiling

trials

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TAILORx

pairings

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Gene-expression assay → chemotherapy omission

people

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René Bernards