Avelumab
Avelumab is a PD-L1 blocker given as maintenance after chemotherapy for advanced bladder cancer, which lengthened survival by about seven months.
JAVELIN Bladder 100 (OS 21.4 vs 14.3 months) made avelumab maintenance the standard after platinum in 2020. Also approved in Merkel cell carcinoma and (with axitinib) RCC. Largely displaced in first-line urothelial cancer by EV + pembrolizumab. Merck KGaA / Pfizer.
1.Binds PD-L1 on tumour and myeloid cells
- Route
- Intravenous
- Schedule
- 800 mg every 2 weeks until progression, started within 10 weeks of last chemotherapy
- Medicare
- Part B (clinician-administered)
Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies.
- Commercial insurance
- covered with prior authorisation
Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments.
- Assistance programmes
- EMD Serono CoverOne
- Pfizer Oncology Together
- Pfizer RxPathways
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.
- Appraised for
- Maintenance for urothelial cancer after platinum chemotherapy (JAVELIN Bladder 100)
- Notes
- Merkel cell carcinoma was appraised in TA517 (2018).
- NHS England
- Routinely funded for the appraised indication (or via managed access)
Sources: NICE TA788 · SMC advice: avelumab. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2017 | Merkel cell carcinoma; urothelial cancer after platinum (accelerated) |
| US | 2020 | Maintenance after first-line platinum in advanced urothelial cancer |
| Adverse event | Any grade | Grade 3+ |
|---|---|---|
| Fatigue | 18% | — |
| Pruritus | 17% | — |
| Hypothyroidism | 12% | — |
| Immune-related grade 3+ | — | 7% |
Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"Avelumab" OR ABSTRACT:"Avelumab" OR TITLE:"Bavencio" OR ABSTRACT:"Bavencio") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Avelumab, not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductRetifanlimab
Shares Merkel cell carcinoma, Oncogenic viruses, Immune checkpoint inhibitors.
- InstitutionCedars-Sinai Cancer
Shares Renal cell carcinoma, Bladder & urothelial cancer, Immune checkpoint inhibitors.
- PersonPadmanee Sharma
Shares Renal cell carcinoma, Bladder & urothelial cancer, Immune checkpoint inhibitors.
- ProductCosibelimab
Shares PD-L1, Immune checkpoint inhibitors.
- IdeaAnchor a TGF-beta trap in the tumour stroma so it cannot act everywhere
Shares PD-L1, Bladder & urothelial cancer, Immune checkpoint inhibitors.
- TrialJAVELIN Head and Neck 100
Shares PD-L1, Immune checkpoint inhibitors.
- ProductTemsirolimus
- PersonMatthew D. Galsky
Shares PD-L1, Bladder & urothelial cancer.