COG ANBL0532
COG ANBL0532 showed that two transplants in a row beat one in high-risk neuroblastoma.
3-year EFS 61.6% vs 48.4% (JAMA 2019); with subsequent anti-GD2 immunotherapy, 3-year EFS 73.7% vs 56.0%. OS not significantly different at 3 years. Tandem transplant became the North American standard.
- 61.6 vs 48.4 out of 100 free of a major event at 3 years with Tandem transplant compared with Single transplant; 13.2 more per 100.
- Roughly one extra person helped for every 8 treated. That is a rough figure taken from the two percentages, not a guarantee for any one person.
- The p-value (0.006) says a difference this large would rarely happen by chance; it does not say how large or how useful the difference is.
- This is a surrogate endpoint: it measures the cancer being controlled or absent on scans and tests, which often, but not always, translates into living longer.
- These results apply to the people the trial enrolled: High-risk neuroblastoma: tandem vs single autologous transplant after induction. People in a different situation may not see the same effect.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
Pages like this
not linked directly; found by shared links- TrialCOG ANBL0032
Shares Julie R. Park, Children's Oncology Group (COG), Neuroblastoma (paediatric).
- InstitutionSt. Jude Children's Research Hospital
Shares Julie R. Park, Children's Oncology Group (COG), Neuroblastoma (paediatric).
- IdeaMake paediatric combination studies part of every relevant adult cancer drug approval
Shares Children's Oncology Group (COG), Neuroblastoma (paediatric).
- IdeaAn international consortium pooling the outcome of every treated child with cancer
Shares Children's Oncology Group (COG), Neuroblastoma (paediatric).
- PersonKatherine K. Matthay
Shares Children's Oncology Group (COG), Neuroblastoma (paediatric).
- IdeaEscrow a share of adult revenue until the paediatric study is done
Shares Children's Oncology Group (COG), Neuroblastoma (paediatric).
- TrialSIOPEN HR-NBL1
Shares Autologous stem cell transplant (high-dose therapy), Neuroblastoma (paediatric).
- TrialCOG ANBL1531
Shares Children's Oncology Group (COG), Neuroblastoma (paediatric).