termsTerm
Reed-Sternberg cell
The Reed-Sternberg cell is the giant, often two-nucleus cancer cell of Hodgkin lymphoma; it makes up only about 1% of the tumour, and the rest is immune cells it has recruited.
Crippled germinal-centre B cells that have lost their B-cell programme, express CD30 and CD15, carry 9p24.1 (PD-L1/PD-L2) amplification in most cases, and are often EBV-positive. Their dependence on PD-L1 explains why Hodgkin lymphoma is the most checkpoint-inhibitor-responsive cancer (ORR ~70% for nivolumab or pembrolizumab in relapse).
Biology: what this kind of term is about · animated schematic, not to scale
Category
Biology