High-throughput screening and DNA-encoded libraries
Testing millions or billions of chemical compounds against a cancer target automatically to find starting points for new drugs.
Robotic HTS of 1-2 million compound libraries, fragment screening by NMR or crystallography, DNA-encoded libraries (X-Chem, HitGen, WuXi; billions of compounds per pool), affinity-selection mass spectrometry, and virtual screening of ultra-large make-on-demand spaces (Enamine REAL, tens of billions) supply hits; CRISPR pooled screens (Broad DepMap, Sanger) supply the targets. Automation vendors: Beckman, Hamilton, Tecan, Thermo Fisher; readouts increasingly imaging-based (cell painting).
How it works
Parallel assays in microtitre plates or barcoded pools identify binders or phenotypic modulators, followed by hit confirmation and medicinal chemistry.
- Unbiased hit discovery
- DEL and virtual screening explore vast chemical space cheaply
- False positives and assay artefacts
- Hits far from drugs
- Undruggable targets still resist
Latest papers
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