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Teaching pack: Epigenetic & Transcriptional Therapy

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  1. Teaching pack · Front

    Epigenetic & Transcriptional Therapy

    Epigenetic and transcriptional therapy changes how genes are read rather than the genes themselves.

    Teaching pack: Epigenetic & Transcriptional Therapy · OnCo, CC BY 4.0 · not medical advice1 / 3
  2. What it is

    In two paragraphs

    DNMT and HDAC inhibitors (haematologic malignancies), EZH2 inhibitors, IDH inhibitors, menin inhibitors (revumenib), BET inhibitors, and emerging transcription-factor degraders. Mostly established in blood cancers; solid tumours are catching up.

    Teaching pack: Epigenetic & Transcriptional Therapy · OnCo, CC BY 4.0 · not medical advice2 / 3
  3. Technologies

    The ways in on this front

    • Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET): Drugs that change how genes are switched on and off without changing the DNA itself.
    • Epigenetic editing (durable gene silencing): Switching a gene off for good without changing the DNA sequence, by writing chemical marks onto it.
    Teaching pack: Epigenetic & Transcriptional Therapy · OnCo, CC BY 4.0 · not medical advice3 / 3