Test flat versus weight-based dosing of antibodies, and use dose banding to cut waste
Many antibody drugs moved from doses based on body weight to one fixed dose for everyone, which is convenient but means lighter patients get relatively more drug. Trials comparing the two, plus rounding doses to standard vial sizes, could keep effectiveness while cutting cost and waste.
Randomised or PK-bridging comparisons of flat versus weight-based (or weight-banded) dosing for monoclonal antibodies and ADCs where flat dosing was adopted on modelling alone; pharmacy dose-banding and vial sharing implemented as policy where exposure equivalence is shown. Payers fund the trials; savings are large because these agents dominate oncology drug spend.
- Wrong doses · Most drug doses were chosen as the highest a person can tolerate, which is often more than they need.
- Prices and value · New cancer drugs routinely cost over $150,000 a year, often for months of benefit. Systems cannot afford them and patients go bankrupt.
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not linked directly; found by shared links- IdeaRestore weight-based dosing and vial sharing for immunotherapy in the label
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