Open-source protocol and statistical analysis plan templates with runnable code
Every trial writes its protocol and analysis plan from scratch. A shared library of well-written templates and ready-to-run analysis code would let teams start from the best version rather than a blank page.
A curated public repository of oncology protocol templates (by design type), statistical analysis plans with executable code (R/Python) for standard endpoints, adaptive designs and estimands, and eligibility criterion libraries with computable definitions. Maintained by cooperative groups and statistical societies with version control and peer review, building on the TransCelerate common protocol template and CDISC standards.
- Trial design, endpoints and cost · A phase 3 trial takes years and hundreds of millions of dollars, and often answers a question that has already moved on.
- Knowledge reaches practice too slowly · Knowledge diffusion is slow: it takes years for a proven result to change what most patients receive, and no one can keep up with the literature.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
Pages like this
not linked directly; found by shared links- IdeaRandomised trials of how to spread proven cancer treatments, not just what works
Shares Knowledge reaches practice too slowly, National Cancer Institute (NIH).
- IdeaAutomatic flagging of retracted or corrected evidence in guidelines and decision support
Shares Preclinical results do not reproduce, Knowledge reaches practice too slowly.
- IdeaPublicly funded cancer AI must release open weights and model cards
Shares Preclinical results do not reproduce, National Cancer Institute (NIH).
- IdeaLiving plain-language evidence summaries for every common cancer question in 20 languages
Shares Knowledge reaches practice too slowly, National Cancer Institute (NIH).
- IdeaPublish per-patient trial cost benchmarks and target halving them
Shares National Cancer Institute (NIH), Trial design, endpoints and cost.
- IdeaA home for the animal and organoid experiments that failed
Shares Preclinical results do not reproduce, National Cancer Institute (NIH).
- IdeaPre-register animal efficacy studies like clinical trials
Shares Preclinical results do not reproduce, National Cancer Institute (NIH).
- IdeaA public biomarker validation utility with pre-diagnostic biobanks and blinded testing
Shares Preclinical results do not reproduce, National Cancer Institute (NIH).