Bank three spatially separate tumour blocks from every resection
Hospitals usually keep one piece of a removed tumour. Keeping three pieces from different parts would show how varied the tumour is, at almost no extra cost.
TRACERx showed that a single region misses subclonal drivers and under-calls copy-number heterogeneity in a large share of lung cancers. Pathology protocols could mandate three or more spatially annotated blocks (core, edge, invasive front) frozen and formalin-fixed for every resected solid tumour, with the region map stored with the specimen. The marginal cost is technician time; the payoff is a national multi-region resource attached to outcomes.
- Tumour heterogeneity and clonal evolution · A tumour is many tumours. Treatments that kill most cells leave the rest to grow back, changed.
- Data silos · Records, scans, genomes and outcomes sit in separate systems that cannot talk. Every patient's experience is lost to the next.
Pages like this
not linked directly; found by shared links- IdeaPool every multi-sample tumour genome into one open evolution atlas
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Whole-exome & whole-genome sequencing, Cancer Research UK.
- InstitutionOntario Institute for Cancer Research
Shares Tumour heterogeneity and clonal evolution, Whole-exome & whole-genome sequencing, Data silos, Comprehensive genomic profiling.
- IdeaA national rapid research autopsy network for end-stage cancer
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Whole-exome & whole-genome sequencing, Cancer Research UK.
- Key paperGerlinger: a single biopsy misses most of the mutations in a kidney tumour
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Whole-exome & whole-genome sequencing, Cancer Research UK.
- InstitutionWellcome
Shares The Francis Crick Institute, Whole-exome & whole-genome sequencing, Cancer Research UK, Data silos.
- IdeaA standard evolvability score for every tumour
Shares Tumour heterogeneity and clonal evolution, Whole-exome & whole-genome sequencing, Comprehensive genomic profiling.
- IdeaLook for the resistant sub-population before the first dose
Shares Tumour heterogeneity and clonal evolution, Comprehensive genomic profiling, Colorectal cancer, Non-small-cell lung cancer.
- InstitutionCancer Grand Challenges
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Cancer Research UK, Colorectal cancer.