Platinum + etoposide (EP / CE)
Platinum plus etoposide has been the chemotherapy backbone of small-cell lung cancer for over 40 years, and is now given with immunotherapy.
Cisplatin or carboplatin with etoposide for 4 (extensive-stage) to 4-6 (limited-stage, with concurrent radiotherapy) cycles. Response rates 60-80% but relapse is near-universal in extensive-stage disease. Carboplatin is preferred with immunotherapy and in frailer patients; cisplatin with concurrent thoracic radiotherapy in fit limited-stage patients.
1.Platinum forms intrastrand DNA crosslinks
- Route
- Intravenous
- Schedule
- Carboplatin AUC 5 day 1 (or cisplatin 75 mg/m² day 1) + etoposide 100 mg/m² days 1-3, every 21 days, 4 cycles
- Dose modifications
- Dose reductions for neutropenia; G-CSF support with concurrent radiotherapy is avoided
- Monitoring
- Blood counts each cycle; renal function and hearing with cisplatin
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1983 | Etoposide approved for SCLC; platinum-etoposide became standard in the 1980s |
| Adverse event | Any grade | Grade 3+ |
|---|---|---|
| Neutropenia (grade 3+) | — | 40% |
| Anaemia | 40% | — |
| Nausea | 50% | — |
| Alopecia | 60% | — |
Range across trials 23-45%. Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
Trials
topRecruiting now (live from ClinicalTrials.gov)
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"Platinum + etoposide" OR ABSTRACT:"Platinum + etoposide" OR TITLE:"EP / CE" OR ABSTRACT:"EP / CE") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Platinum + etoposide (EP / CE), not a curated reading list.
Pages like this
not linked directly; found by shared links- PersonAnne C. Chiang
Shares IMpower133, Small-cell lung cancer.
- ProductSerplulimab
Shares ASTRUM-005, Small-cell lung cancer.
- TrialIMforte
Shares Chemo-immunotherapy induction → maintenance intensification (SCLC), Small-cell lung cancer.
- ProductNALIRIFOX (liposomal irinotecan + oxaliplatin + 5-FU/LV)
Shares Topoisomerase-I inhibitors (and ADC payloads), Platinum agents, Cytotoxic chemotherapy.
- TrialDeLLphi-305
Shares Chemo-immunotherapy induction → maintenance intensification (SCLC), Small-cell lung cancer.
- ProductLurbinectedin
Shares Chemo-immunotherapy induction → maintenance intensification (SCLC), Small-cell lung cancer, Cytotoxic chemotherapy.
- Key paperNAPOLI-3: NALIRIFOX versus gemcitabine plus nab-paclitaxel as first treatment for metastatic pancreatic cancer
Shares Topoisomerase-I inhibitors (and ADC payloads), Platinum agents, Cytotoxic chemotherapy.
- ProductFOLFIRINOX / mFOLFIRINOX
Shares Topoisomerase-I inhibitors (and ADC payloads), Platinum agents, Cytotoxic chemotherapy.