Binimetinib
Binimetinib is the MEK inhibitor partnered with encorafenib; blocking the next step in the same relay stops the tumour rerouting around the BRAF block.
Approved June 2018 with encorafenib for BRAF V600 melanoma (COLUMBUS) and 2023 for BRAF V600E NSCLC. Class effects: retinopathy (serous retinal detachment), CK elevation, left-ventricular dysfunction, rash, diarrhoea.
1.Binds MEK1/2 outside the ATP site and locks them in an inactive conformation
- Route
- Oral
- Schedule
- 45 mg twice daily with encorafenib 450 mg once daily
- Dose modifications
- Hold for retinopathy, LVEF drop, CK rise
- Monitoring
- Ophthalmology at baseline and for symptoms; echocardiogram; CK
Source: www.accessdata.fda.gov/drugsatfda_docs/label/2023/210498s009lbl.pdf. Doses are for orientation; the current label governs.
- Medicare
- Part D (self-administered)
Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026).
- Commercial insurance
- covered with prior authorisation
Covered for FDA-labelled and NCCN-listed uses, but almost always behind prior authorisation confirming diagnosis, biomarker and line of therapy; dispensed through a specialty pharmacy.
- Assistance programmes
- Pfizer Oncology Together
- Pfizer RxPathways
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
Part D out-of-pocket capped at $2,000 (2025) / $2,100 (2026). Medicare patients cannot use manufacturer co-pay cards; charity funds (PAN, HealthWell, CancerCare) and the Extra Help subsidy are the routes.
Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.
- Appraised for
- With encorafenib for BRAF V600 mutation-positive melanoma
- NHS England
- Routinely funded for the appraised indication (or via managed access)
Sources: NICE TA562 · SMC advice: binimetinib. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
- 27 Jun 2018ApprovalUS
Encorafenib + binimetinib approved for BRAF V600 melanoma
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2018 | BRAF V600E/K melanoma with encorafenib |
| US | 2023 | BRAF V600E metastatic NSCLC with encorafenib |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"Binimetinib" OR ABSTRACT:"Binimetinib" OR TITLE:"Mektovi" OR ABSTRACT:"Mektovi") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Binimetinib, not a curated reading list.
Pages like this
not linked directly; found by shared links- PairingBRAF inhibitor + MEK inhibitor
Shares Encorafenib, BRAF, RAS / RAF / MEK / ERK (MAPK), Melanoma.
- ProductVemurafenib
Shares COLUMBUS, BRAF, RAS / RAF / MEK / ERK (MAPK), Small-molecule kinase inhibitors.
- TrialCOMBI-AD
Shares BRAF, RAS / RAF / MEK / ERK (MAPK), Melanoma.
- ProductDacomitinib
Shares Pfizer (incl. Seagen), Small-molecule kinase inhibitors, Non-small-cell lung cancer.
- ProductCobimetinib
Shares BRAF, RAS / RAF / MEK / ERK (MAPK), Small-molecule kinase inhibitors, Melanoma.
- IdeaTest intermittent dosing of targeted drugs to delay resistance, with honest priors
Shares BRAF, Small-molecule kinase inhibitors, Melanoma, Non-small-cell lung cancer.
- PairingImmunotherapy first, then BRAF/MEK (BRAF-mutant melanoma)
Shares Encorafenib, BRAF, Melanoma.
- IdeaPause a failed drug so the tumour becomes sensitive to it again
Shares Encorafenib, Melanoma, Non-small-cell lung cancer.