OnCo
drugsProductNot mapped hereapproved

Bendamustine

An East German chemotherapy rediscovered in the 2000s that became the backbone partner for rituximab in follicular, mantle cell and Waldenström lymphomas.

Approved 2008 for CLL and rituximab-refractory indolent NHL. StiL and BRIGHT trials showed bendamustine-rituximab at least as effective as R-CHOP with less alopecia and neuropathy, making BR the most common first-line indolent lymphoma regimen. Prolonged lymphopenia and infections (PJP, CMV) are the main concerns; combined with obinutuzumab (GALLIUM) or acalabrutinib (ECHO).

Loading structure…
|
Bendamustine
PubChem
Modality
Alkylating agent (nitrogen mustard-purine hybrid)
Mechanism
Bifunctional alkylator causing DNA cross-links with a benzimidazole ring conferring purine-analogue-like properties; less cross-resistance with other alkylators.
Brand / code
Treanda / Bendeka / Belrapzo
Medicare
Part B (clinician-administered)

Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. Bendeka and Belrapzo are branded; generic bendamustine is available.

Commercial insurance
covered on label

Multi-source generic; covered under the medical benefit without prior authorisation in most plans, as part of standard regimens. Plans may prefer a specific bendamustine product.

Assistance programmes

Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.

NICE recommendedNICE TA216 · 2011SMC: accepted
Appraised for
First-line CLL (Binet B/C) when fludarabine combination is not appropriate
Notes
Generic; also used in lymphoma regimens (BR) and as the partner in TA472 and TA649.
NHS England
Routinely funded for the appraised indication (or via managed access)

Sources: NICE TA216 · SMC advice: bendamustine. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.

Regulatory

2top

Approvals

RegionYearIndication
US2008CLL; indolent B-cell NHL progressed within 6 months of rituximab
EU2010CLL, indolent NHL, multiple myeloma (national approvals)

Trials

top
ClinicalTrials.gov · phase 2/3
refreshed 2026-09-09
331 studies9 recruiting79 Phase 224 Phase 3
Search “Bendamustine” on ClinicalTrials.gov →
Counts are from a name search and may include unrelated studies; up to 100 studies are summarised.

Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
Bendamustine
intervention: Bendamustine
Open on ClinicalTrials.gov →

Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.

Key papers

1top

Latest papers

top
Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"Bendamustine" OR ABSTRACT:"Bendamustine" OR TITLE:"Treanda" OR ABSTRACT:"Treanda" OR TITLE:"Bendeka" OR ABSTRACT:"Bendeka" OR TITLE:"Belrapzo" OR ABSTRACT:"Belrapzo") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Bendamustine, not a curated reading list.

Connected

8top

Pages like this

not linked directly; found by shared links