Abiraterone acetate
Abiraterone is a pill that shuts down testosterone production everywhere, including inside the tumour. Discovered at the Institute of Cancer Research, now generic and used from the first metastatic diagnosis.
COU-AA-301/302 (mCRPC post- and pre-docetaxel), LATITUDE and STAMPEDE (mHSPC, OS benefit), PEACE-1 (triplet with docetaxel). Given with prednisone. Generic since 2018-19; backbone partner for PARP inhibitors (PROpel, MAGNITUDE), capivasertib (CAPItello-281), and Pluvicto (PSMAddition).
- Medicare
- Part D (self-administered)
Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026). Generic abiraterone (since 2018) is inexpensive; the Yonsa formulation and brand Zytiga cost far more.
- Commercial insurance
- covered on label
Multi-source generic on low-cost tiers; usually no prior authorisation. Cash prices without insurance are modest. Many plans require generic abiraterone before enzalutamide or other novel hormonal agents.
- Assistance programmes
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.
- Appraised for
- Metastatic castration-resistant prostate cancer after docetaxel
- Notes
- Before chemotherapy: TA387 (2016). Newly diagnosed high-risk hormone-sensitive disease (STAMPEDE/LATITUDE) was not recommended in TA721 (2021), but abiraterone went generic in 2022 and NHS England commissioned it for mHSPC via national policy.
- NHS England
- Routinely funded for the appraised indication (or via managed access)
Sources: NICE TA259 · SMC advice: abiraterone. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2011 | mCRPC after docetaxel |
| US | 2012 | mCRPC pre-chemotherapy |
| US | 2018 | High-risk mHSPC (LATITUDE) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"Abiraterone acetate" OR ABSTRACT:"Abiraterone acetate" OR TITLE:"Zytiga" OR ABSTRACT:"Zytiga" OR TITLE:"generic" OR ABSTRACT:"generic") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Abiraterone acetate, not a curated reading list.
Pages like this
not linked directly; found by shared links- Key paperSTAMPEDE: adding abiraterone to hormone therapy at diagnosis of advanced prostate cancer
Shares Nicholas James, Johann de Bono, Androgen deprivation & AR pathway inhibitors, The Institute of Cancer Research.
- ProductEnzalutamide
Shares Howard I. Scher, Androgen receptor pathway inhibitor (ARPI), Prostate Cancer Foundation (PCF), mCRPC and mHSPC (castration-resistant vs hormone-sensitive prostate cancer).
- ProductBicalutamide
Shares Androgen receptor pathway inhibitor (ARPI), Androgen deprivation & AR pathway inhibitors, Androgen receptor signalling, Androgen receptor.
- ProductApalutamide
Shares Androgen deprivation & AR pathway inhibitors, Androgen receptor signalling, Johnson & Johnson, Androgen receptor.
- TermCastration-resistant prostate cancer (CRPC)
Shares Androgen receptor pathway inhibitor (ARPI), Prostate Cancer Foundation (PCF), mCRPC and mHSPC (castration-resistant vs hormone-sensitive prostate cancer), Androgen receptor signalling.
- ProductCapivasertib
Shares CAPItello-281, Paul Workman, Androgen receptor signalling, The Institute of Cancer Research.
- TermAndrogen deprivation therapy (ADT)
Shares Androgen receptor pathway inhibitor (ARPI), mCRPC and mHSPC (castration-resistant vs hormone-sensitive prostate cancer), Androgen deprivation & AR pathway inhibitors, Prostate cancer.
- ProductDarolutamide
Shares Androgen deprivation & AR pathway inhibitors, Androgen receptor signalling, Androgen receptor, Prostate cancer.