[{"id":"keap1-nrf2","kind":"pathway","name":"KEAP1–NRF2 antioxidant pathway","route":"/pathways/keap1-nrf2/","commit":"0bdbdae6c6","date":"2026-09-09","author":"Jude Gomila","message":"Editing pass: every TL;DR and summary stands alone","file":"src/data/mechanisms.ts","type":"changed","fields":[{"field":"tldr","before":"\"The cell's antioxidant defence switch. Lung cancers often break the off-switch (KEAP1), leaving NRF2 permanently on, which detoxifies chemotherapy and radiation and makes these tumours resistant to almost everything.\"","after":"\"KEAP1–NRF2 is the cell's antioxidant defence switch. Lung cancers often break the off-switch (KEAP1), leaving NRF2 permanently on, which detoxifies chemotherapy and radiation and makes these tumours resistant to almo..."},{"field":"analogy","before":"\"A smoke detector wired to a sprinkler system. Cancers jam the detector on, so the sprinklers run constantly and wash away every poison you throw at them.\"","after":"\"KEAP1–NRF2 is a smoke detector wired to a sprinkler system. Cancers jam the detector on, so the sprinklers run constantly and wash away every poison you throw at them.\""}]},{"id":"keap1-nrf2","kind":"pathway","name":"KEAP1–NRF2 antioxidant pathway","route":"/pathways/keap1-nrf2/","commit":"a01207de6c","date":"2026-09-08","author":"Jude Gomila","message":"Mechanism research map: 31 pathway diagrams (metastasis, TME, metabolism, CIN, dormancy, MYC, Hippo, splicing…), 14 hallmark terms + core vo","file":"src/data/mechanisms.ts","type":"added","fields":[{"field":"id"},{"field":"name"},{"field":"wikipedia"},{"field":"tldr"},{"field":"summary"},{"field":"analogy"},{"field":"nodes"},{"field":"edges"},{"field":"interventions"},{"field":"pathways"},{"field":"targets"},{"field":"cancers"},{"field":"terms"},{"field":"institutions"},{"field":"notes"},{"field":"links"},{"field":"tags"}]}]